Leonardo Sepúlveda Durán
- Licenciado en Bioquímica, Universidad de Chile
- Doctor (c) en Biofísica y Biología Computacional, University of Illinois, Estados Unidos
Biología de Sistemas, efectos biológicos del ruido en expresion génica.
Desarrollar nuevas técnicas experimentales para estudiar la regulación génica en bacterias al nivel de células y moléculas individuales.
Premios o Becas:
2007. Robert Emerson Fellowship in Biophysics, University of Illinois at Urbana-Champaign
Publicaciones:
SO, L-H., GHOSH, A., ZONG, C., SEPÚLVEDA, L.A., SEGEV, R. & GOLDING, I. 2011. General properties of transcriptional time series in Escherichia coli. Nature Genetics 43(6):554-60. PMID:21532574
ROTHENBERG, E., SEPÚLVEDA, L.A., SKINNER, S.O., ZENG, L., SELVIN, P.R. & GOLDING, I. 2010. Single-virus tracking reveals a spatial receptor-dependent search mechanism. Biophys. J., 100(12):2875-82. PMID:21689520
ZONG, C., SO, L., SEPÚLVEDA, L.A., SKINNER, S.O. & GOLDING, I. 2010. Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene. Molecular Systems Biology 6:440. PMID:21119634
ROBERTS, E., STONE, J.E., SEPÚLVEDA, L.A., HWU, W.W. & LUTHEY-SCHULTEN, Z. 2009. Long time-scale simulations of in vivo diffusion using GPU hardware. In Proceedings of the 2009 IEEE International Symposium on Parallel & Distributed Processing
GONZALEZ, A., SEPÚLVEDA, L.A., ARAYA-SECCHI, R., GARATE, J.A., PESSOA-MAHANA, C.D., LAGOS, C.F. & PEREZ-ACLE, T. 2008. Computational modeling study of functional microdomains in cannabinoid receptor type 1. Bioorg. Med. Chem. 16(8):4378-89. PMID:18342519
Presentaciones en Congresos:
Poster, XX Annual meeting of the Chilean Cellular Biology Society “Effect of the interaction interphase between FtsZ amino and carboxy-terminal domains on their folding.” Leonardo Sepúlveda, Tomás Pérez-Acle, Octavio Monasterio. Octubre 2006
Poster, XX Annual meeting of the Chilean Cellular Biology Society “In silico Study of activation mechanism in Cannabinoid receptors (CB1)” Angel Gonzalez, Leonardo Sepúlveda, Carlos Lagos, Jose A. Garate, Raúl Araya-Secchi & Tomas Pérez-Acle. Octubre 2006
Talk, 3rd Bioinformatics workshop, Universidad Andres Bello. Name of the talk: “Comparison of Implicit and Explicit Solvent Models in the Thermal Unfolding of Chymotrypsin Inhibitor 2″. Septiembre 2005
Poster, XVII Annual meeting of the Chilean Cellular Biology Society. Name: “Study of the self-organization of Diphenilalanine peptides in nanotubular structures”. Octubre 2003
Investigaciones:
Asistente de investigación, Baylor College of Medicine, USA. 2010 al presente.
Center of Biophysics and Computacional Biology, University of Illinois at Urbana-Champaign. Advisors: Ido Golding and Zaida Luthey-Schulthen. Enero 2008.
Undergraduate thesis in Biochemistry, Structural and Molecular Biology laboratory (BEM), Faculty of Sciences, Universidad Chile, and Center of Genomics and Bioinformatics (CGB), College of Biology, P. Universidad Católica de Chile. Advisors: Dr. Octavio Monasterio Opazo and Tomás Perez-Acle. Noviembre 2004 – Diciembre 2006.
Professional Practice. Center of Genomics and Bioinformatics (CGB) P. Universidad Católica de Chile. Noviembre 2003- Octubre 2004.
Training in Bioinformatics, Center of Genomics and Bioinformatics (CGB), College of Biology, P. Universidad Católica de Chile. Octubre 2003 – Marzo 2003.
Practice, Physical Chemistry and Photochemistry laboratory, College of Chemistry and Pharmacy, Universidad de Chile. Enero 2003.
Cursos:
“Structural Bioinformatics workshop 2006: Molecular Simulations of Transmembrane proteins: VMD & NAMD” Center of Bioinformatics and Molecular Simulation (CBSM) Universidad de Talca, Chile. Noviembre 2006.
“From Sequence to Structure and Function” Center of Bioinformatics and Molecular Simulation (CBSM) Universidad de Talca, Chile. Octubre 2005.
“2nd course of advanced Bioinformatics“. Structural and Molecular Biology laboratory (BEM), Faculty of Sciences, Universidad Chile. Enero 2005.
“Kinetics: From Enzymes to Metabolic Pathways“; Biochemistry institute, Faculty of Sciences, Universidad Austral de Chile. Octubre 2003.
CIMPA-UNESCO SUMMER SCHOOL, “Mathematical and Computational Methods in Biology“; Center of Scientific Studies (CECS), Valdivia, Chile. Enero 2004
Docencia:
2010, 2012. Ayudante, Center for the Physics of Living Cells Summer School
2011. Ayudante, Caltech Bioengineering Bootcamp
2006. Ayudante, Introducción a la Bioinformática